ID   PAHO_CHICK     STANDARD;      PRT;    80 AA.
AC   P01306;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   01-FEB-1996 (REL. 33, LAST SEQUENCE UPDATE)
DT   01-FEB-1996 (REL. 33, LAST ANNOTATION UPDATE)
DE   PANCREATIC HORMONE PRECURSOR (PANCREATIC POLYPEPTIDE) (PP).
OS   GALLUS GALLUS (CHICKEN), AND MELEAGRIS GALLOPAVO (COMMON TURKEY).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; ARCHOSAURIA; AVES;
OC   NEOGNATHAE; GALLIFORMES; PHASIANIDAE; PHASIANINAE; GALLUS.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   SPECIES=CHICKEN; TISSUE=LIVER;
RX   MEDLINE; 93366173.
RA   NATA K., SUGIMOTO T., KOHRI K., HIDAKA H., HATTORI E., YAMAMOTO H.,
RA   YONEKURA H., OKAMOTO H.;
RT   "Structure determination and evolution of the chicken cDNA and gene
RT   encoding prepropancreatic polypeptide.";
RL   GENE 130:183-189(1993).
RN   [2]
RP   SEQUENCE OF 26-61.
RC   SPECIES=CHICKEN;
RX   MEDLINE; 76069270.
RA   KIMMEL J.R., HAYDEN L.J., POLLOCK H.G.;
RT   "Isolation and characterization of a new pancreatic polypeptide
RT   hormone.";
RL   J. BIOL. CHEM. 250:9369-9376(1975).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS).
RC   SPECIES=M.GALLOPAVO;
RX   MEDLINE; 84179397.
RA   GLOVER I., MANEEF I., PITTS J., WOODS S., MOSS D., TICKLE I.,
RA   BLUNDELL T.L.;
RT   "Conformational flexibility in a small globular hormone: X-ray
RT   analysis of avian pancreatic polypeptide at 0.98-A resolution.";
RL   BIOPOLYMERS 22:293-304(1983).
CC   -!- FUNCTION: PANCREATIC HORMONE IS SYNTHESIZED IN PANCREATIC ISLETS
CC       OF LANGERHANS AND ACTS AS A REGULATOR OF PANCREATIC AND
CC       GASTROINTESTINAL FUNCTIONS.
CC   -!- SIMILARITY: BELONGS TO THE PP FAMILY (PANCREATIC HORMONE,
CC       NEUROPEPTIDE Y, PEPTIDE YY).
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DR   EMBL; D13761; G391634; -.
DR   EMBL; D13760; G391646; -.
DR   PIR; A01575; PCCH.
DR   PDB; 1PPT; 15-OCT-91.
DR   PROSITE; PS00265; PANCREATIC_HORMONE; 1.
DR   PFAM; PF00159; hormone3; 1.
KW   HORMONE; CLEAVAGE ON PAIR OF BASIC RESIDUES; PANCREAS; SIGNAL;
KW   AMIDATION; 3D-STRUCTURE.
FT   SIGNAL        1     25       POTENTIAL.
FT   CHAIN        26     61       PANCREATIC HORMONE.
FT   MOD_RES      61     61       AMIDATION (G-62 PROVIDE AMIDE GROUP).
FT   CONFLICT     47     48       ND -> DN (IN REF. 2).
FT   TURN         35     36
FT   HELIX        39     56
FT   TURN         57     58
SQ   SEQUENCE   80 AA;  8773 MW;  DE642B29 CRC32;
     MPPRWASLLL LACSLLLLAV PPGTAGPSQP TYPGDDAPVE DLIRFYNDLQ QYLNVVTRHR
     YGRRSSSRVL CEEPMGAAGC
//